Changes in Holography

Changes in Holography 001 Looking Back, Moving Forward How was 2004 for you? For the industry as a whole, reviewing the developments that we covered last year in Holography News, we can conclude that it was a good year for most, with many positive developments that set the scene for 2005 and beyond, but with sufficient clouds on the horizon to prevent any complacency. In terms of markets, in the high security arena the growth of holograms on banknotes continues apace (see page 3) and this will continue to be key market notwithstanding the recent news that the new $100 and other denominations will not, in all likelihood, include a holographic feature. In other high security markets, passports took something of a back seat, for holograms at least not because of technology concerns but because of the current pre-occupation with biometrics. But elsewhere in document protection, AAMVAs specification of holograms on all US driving licences was a significant boost for the industry, while the tax stamp market continues provide significant high volume opportunities for suppliers. There were few major developments in brand protection although the use of holograms as the prime authentication feature on a new labelling program for pharmaceutical products in Malaysia, and the Olympics 2004 merchandising program demonstrated the continuing success of hologram s in these areas. On the downside, the FDAs controversial decision to adopt RFID-based track and trace as the solution to product safety and supply chain management for pharmaceuticals in the US could have unwelcome consequences for the industry should drug regulatory authorities elsewhere in the world follow its example. In packaging, meanwhile, as the Stock watch article in this issue (see page 6) points out, it is barely possible to go out nowadays without seeing holography embellishing shop shelves on all manner of goods from luxury high end to everyday items. Innovation and Development On the technology front, holography continued to demonstrate its inherent capacity for innovation and development. The integration of holograms with other technologies for enhanced security and functionality continued apace examples including Schreiners KeySecure technology, Securiketts Authentikett labels, combined hologram/DNA/RFID labels from ADNAS and Holomex and enhancements to teas scribos Holospot system (see page 8) to name but a few. In the banknote market, De La Rue, Louisenthal and Kurz all launched new security features during 2004 based on combinations of substrate, thread and foil technology. In terms of production, Newmec and Gidue both entered the market with foil applications systems, General Vacuum launched its new compact metalliser while Spatial Imagings new Lightspeed digital hologram printer marked the beginning of new era in large format hologram origination. Aside from the developments in the ‘conventional market for authentication and decorative devices, holography is also beginning to demonstrate its potential for use as a tool as well as a feature. Examples of this potential include Smart Holograms development of reflection holograms as medical diagnostic devices and holographic data storage systems from Optware. Publicly-listed companies were covered in detail in the December issue of Holography News. But there was news from many other qua rters as well, including the expansion plans announced by ABNH, ITW Covid, AFC and Holoshape, and AET Films move into wide embossing on the packaging front. Louisenthal, a major player in the banknote industry, revealed that it now offers full-scale hologram production, including origination, while its former strategic partner in foils, Hueck Folien, joined the ranks of banknote suppliers with its first order for stripes for the Thai currency, signalling a potentially significant new entrant to the market. Its arrival was partially offset by AOTs decision to abandon banknote foils, while the bankruptcy of another high security supplier, Mantegazza, was staved off by its acquisition by Italian security papermaker Fabriano. Outside of the traditional industry centres of Western Europe and North America, the Far East, India and Eastern Europe and the CIS countries continue to play an increasingly important role not just as markets for western companies but as major centres of developm ent in their own right. Russia, a hotbed of scientific innovation, held its first regional conference this year; the commitment amongst Indian companies to quality and industry standards is an inspiration to us all, while all eyes are currently on China, the location for the 2005 Holo-pack†¢Holo-print which will provide the first opportunity for many western hologram companies to witness the strength and scope of this massive market. 2004s Downside So much for the positive. On the downside, RFID continues to position itself, and be viewed in some quarters, as the ‘silver bullet antidote to counterfeiting and diversion, new technologies such as Nanoventions claim their superiority over diffractive features and high quality counterfeit holograms have been discovered on currency notably the euro. The latter, in particular, is leading to a perceptible sense of disenchantment with holograms in terms of their claimed security benefits, technology proliferation and lax standard s amongst suppliers. This topic has been covered exhaustively in recent issues of Holography News and was one of the main topics for discussion at the recent Holo-pack†¢Holo-print conference in Prague, a positive outcome of which was the openness of debate and willingness amongst industry participants to work collectively to address the real issues that are causing concern and counter the misperceptions behind them. All in all, not a bad year for the industry. Provided the concerns leading to disenchantment in some sectors continues to be recognised and addressed with appropriate measures, and provided hologram companies continue to invest in the new products and techniques that form the lifeblood and future of this industry, 2005 could be even better. 002 A Watershed Year for the IHMA In his Chairmans report to the Annual General Meeting of the International Hologram Manufacturers Association, Hugues Souparis identified the launch of the Secure Hologram Producer Certification Scheme as a watershed for the Association (se HN Vol 18 No 3). This Scheme, run in co-operation with Intergraf, should make a significant contribution to improving procedures in the secure hologram field, and help to raise customer awareness of the need to source secure holograms from a qualified secure producer. Souparis company, Hologram Industries, was the first to be certified, but several others have now applied. Another important development during the year had been the negotiations with the Hologram Manufacturers Association of India (HoMAI), aimed at building a strong relationship between the two associations and serving as a model for the IHMAs relationship with other regional or national hologram associations. An important part of the planned relationship was that the IHMAs Hologram Image Register and HoMAIs Hologram Registry would be linked so that all searches for a hologram match on either database would cover both databases, improving the likelihood of identifying matches which resulted from attempts to source illicit copies of a hologram already in use. He reported that Despite the news that the US Bureau of Engraving and Printing is casting its net wider for security features (see page 1), banknotes continue to be a good market for the holography industry. A number of new banknotes have been introduced during 2004, including two major currencies the new Canadian dollar series which features a stripe and the two higher denominations of the newly-designed Japanese yen, each with a patch. Kurz was the supplier for both, the latter understood to be the largest single hologram order for banknotes in the industry. Other currencies that have introduced holograms to all or most of their the Board was in discussion with the China AntiCounterfeiting Technology As sociation (CATA) with a view to CATA establishing a hologram section, and that the IHMA was also in preliminary discussions with Russian producers interested in an industry organisation there. Souparis also reminded members of IHMAs links with Interpol and other international and national police organisations, saying that he hoped to build on these contacts in the coming year. New Board Members In the elections at the AGM, Souparis was re-elected Chairman a post he can hold for another two years. Wilfried Schipper (Hologram Company Rako) was elected as the European representative on the Board, with Alkis Lembessis (Cavomit and Taurus) as his deputy; Umendra Gupta (Holostik India) was re-elected as Asian representative, with Khalid Khanani (Metatex) as deputy. Randy James (Pacific Holographics) was elected as deputy North American representative and since the AGM the Board has co-opted John Halotek (ITW Covid) as the North American representative, there being no accepted nomination at the meeting. Alex Goncharsky (Computer Holography Centre, Moscow) and Ken Traub (ABNH) remain on the board for a second and fourth year respectively. Spreading the Word In addition to the objectives above, a key task for the IHMA in 2005 and thereafter will be to promote the positive benefits of holograms, particularly as authentication devices, as a counter to disenchantment with the technology in certain quarters, notably some parts of the high security sector. A proactive PR campaign, a greater presence at industry conferences, an improved website as a communications tool both for members and users, and a drive to increase the membership and the visibility of the IHMA are all currently underway. The hologram industry is one of the few in the authentication sector to have its own association and the IHMA is committed to building on this position and the strengths that a collective voice can provide for hologram companies. Contact: www.IHMA.org. 003 General Vacuums New Compact Metalliser (Pg # 5) General Vacuum, manufacturer of vacuum metallising equipment, unveiled further details of its new compact Holosecâ„ ¢ metalliser (see HN Vol 18 No 2) at the recent Holo-pack†¢Holo-print conference in Prague. Vacuum metallisers have until now been supplied with production widths of 800-3000m, limiting their use both financially and for production purposes among small and narrow-web hologram producers and forcing these to buy in their film and foil pre-metallised from wide web suppliers. The Holosec was designed to fill this niche and enable narrow-web producers to bring metallising in-house, thereby increasing their security of production and enabling them to take advantage of the specialised treatments the system offers. The Holosec combines the vacuum chamber, unwind and rewind units, plasma pre-treatment, demetallization and evaporation source within one compact unit with a footprint of 2m x 3m. In addition to the conventional aluminium used for holographic films and foils, it can coat silicon oxide, chrome, silver and copper and zinc sulphide for high refractive index films. It also offers pattern demetallisation with in-line registration and plasma pre-treatment that enhances the sur face energy of the films to improve adhesion and hence quality. The run rate varies from 10m to a maximum of 200m per minute. General Vacuum, formerly Valmet and now part of the Bobst Group, declined to give prices for the Holosec, stating that these depend on specification. But it can assumed that they will be considerably lower than the prices for wide web systems. When questioned at Holopack.†¢ Holo-print about the risks of spreading low-cost secure hologram production technology in the market, Dr Nadir Ahmed, who gave the presentation on behalf of his former company, commented that the company would check the legitimacy of customers before supply. To date, two machines have been sold with other orders in the pipeline for early 2005. Contact: Andy Jack, General Vacuum Equipment. Tel: +44 1706 622442; [emailprotected] 004 Menzel Vision System for Web Guiding Menzel, a German company specialising in machinery for finishing and inspection machines for textiles, expanded into similar equipment for the plastic films industry in the late 1960s, and at Holopack†¢ Holo-print exhibited a machine vision system for control of web handling machines for holographic films. The system keeps web lines in register to improve the accuracy and quality of slitting, winding/re-winding, stamping and other hologram finishing processes. Based on the companys experience building textile and film web guiding systems, the hologram guiding system can be set to read the edge of the hologram film or a specific part of the pattern in the hologram the camera scans across the width of the film to record the edge position, the registration mark position or the position of a specified image element. Once programmed, it feeds the image data to a sensor and a controller, which in turn adjusts the web guides to maintain the position of the web. The Menzel vision system for holographic film costs around â‚ ¬17- 20,000, depending on the configuration required. Contact: www.menzel.net. 005 Optical Document Security The third edition of the reference book Optical Document Security is now available from publishers Artech House. Written by Rudolf van Renesse, an expert in the field and editor and co-author of the two previous editions (published in 1994 and 1998 respectively), the book provides a comprehensive and cohesive treatment of all aspects of optical document security, according to its publishers. The books contents have been substantially updated and revised from the previous edition, and expanded to include coverage of additional security features and evaluation. The introduction on the theory of colours is followed by chapters on light interference and diffraction, substrate-based security, printing inks and printing techniques, printed security patterns (including screen decoded images and digital watermarks), diffractive- and interference-based security features, security design and evaluation and an introduction to biometrics. The emphasis is on both the physics of security features and their value in resisting counterfeiting, while the chapter evaluating security design looks at the human factors of first line document inspection. The books 350 pages contain over 270 black and white illustrations, including live security documents, and an appendix with samples of important security features. In addition, a CD-ROM is included which contains all illustrations of the book in full-colour. Author Rudolf van Renesse was senior research engineer in the Optics Department of TNO Institute of Applied Physics in The Netherlands and is now an independent consultant on document security for government departments and banking and financial institutions. He has extensive experience in the areas of holography, optical inspection techniques, and the theory of colors and document security, and is the author of more than 80 publications in these areas, as well as a contributor to Holography News and its sister publications Authentication News and Currency News. Optical Document Security is available at the discounted price  £72/$118 from Artech House www.artech-house.com 006 Display Holography on the Rise Photopolymer is making progress winning projects that perhaps embossed hologram producers might have expected to supply We feel for Nick Hardy and Valerie Love of OpGraphics, the British company that has listed its DuPont photopolymer hologram production equipment for sale on eBay. Op has been producing display holograms for the gift and promotional trade since 1983, originally on Agfa silver halide films, then in the 1990s Nick Hardy started working with DuPonts holographic photopolymer, partly because Agfa ceased production of its holographic films, partly because the photopolymer reflection holograms had lower noise and were more light efficient. Unfortunately, when DuPont Authentication Systems was established as a joint venture with Label Systems Inc, the company decided to restrict the distribution of its unexposed photopolymer film to authorised security hologram producers. Op were among the hologram producers which were given notice of a cessation of supply. They tried to fight this under competition law in the UK, but despite their significant investment in DuPonts production equipment and the time to perfect their processes, this was to no avail. The result: holographic production kit being offered on eBay. The Year of Photopolymer? The timing could not be more poignant as there appears to be an upsurge of interest in photopolymer holograms could 2005 be the year of photopolymer? The year has started well for DAS with NASCARs announcement of its licensed product authentication label, a numbered photopolymer reflection hologram (see page 4). To date, the North American sports licensing authentication projects have been dominated by embossed holograms. NASCAR (the most popular motor sport organisation in North America) may not rival the big national sporting leagues in popularity, but big race meetings such as Daytona and Indianapolis attract large crowds of eager souvenir hunters. Last year, DAS released its izonâ„ ¢ advanced photopolymer holograms, offering instant holo portraits on the film, making it particularly suitable for ID documents. And across the Pacific, Dai Nippon and Nippon Paint Co announced that Teikoku Piston Ring Co had become the first major customer for authentication holograms on Secure I mageâ„ ¢ hot-stampable photopolymer. So photopolymer is making progress in the brand protection market, perhaps winning projects that embossed hologram producers might have expected to supply. Two announcements do not make a fully-fledged market, but do represent progress. Coming Full Circle And now, coming full circle, Liti Holographics has announced that it is shipping a new instant holographic film suitable for reflection holograms for the home and hobby market (see page 3). Meanwhile, silver halide display holograms remain a force in the marketplace. Slavich continues to find a market in Russia and beyond for its silver halide plates and films, and Colour Holographics, which took over the production and supply of HRT holographic plates, finds a steady if not spectacular market. The company is finding a ready market for its own large format co lour holograms, while other silver halide display hologram producers remain in steady production. The availability of compact LED lights which illuminate holograms at a very high quality, and the improved recognition by holographers that they have to deliver a complete, lit and framed installation, is boosting the readiness of display artists and interior designers to consider display holograms as a medium. As one who first got involved in holography because of the excitement of such 3D images, it is reassuring and somewhat surprising to see the continuing interest in full parallax holograms, complementing and supplementing the large volume market of embossed holograms. 007 Litis New Reflection Film Liti Holographics, which offers low cost portrait hologram kits selling for $99 (see HN Vol 18, No 9), has launched a new hologram film. According to the company, this film has all the ‘instant hologram qualities of its previous film but is now capable of making reflection as well as transmission holograms. The new film is red-sensitive, making it compatible with both the Litiholo and other hologram kits, as well as red laser diodes and even helium neon lasers. Contact: www.litiholo.com 008 Nigerias New Pharma Certificate NAFDAC, the Nigerian Food Drugs Agency, has introduced a new certificate to be issued to authorised imported and domestically produced pharmaceuticals. The new certificate is being produced by a security printer in the UK and includes a hologram among its security features. This follows participation by Dr Dora Akunyili, Director of NAFDAC in the first Global Forum on Pharmaceutical AntiCounterfeiting, where she made contact with possible suppliers among the exhibitors. 009 Pharmaceuticals: a Hologram Market Expanding or Threatened? At the time of writing, the 2nd Global Forum on Pharmaceutical AntiCounterfeiting has just finished in Paris, organised by Holography News publisher, Reconnaissance International. One of the themes to emerge during the course of the 21/2 day meeting was the importance of authentication of genuine products as part of the system to combat counterfeit medicines, heard from speakers from national drug regulatory agencies and from pharmaceutical manufacturers. Several of the speakers implied, but Dr Thomas Zimmer of Boehringer Ingelheim explicitly stated, that the ideal authentication device for pharmaceuticals is not yet available. As Dr Zimmer was speaking in his capacity as Chairman of the Anti-Counterfeit Group of the European Federation of the Pharmaceutical Industry Associations (EFPIA), his observations must be taken seriously by suppliers or aspiring suppliers of authentication products to the pharmaceutical sector. To date holograms have been the leading device used for overt authentication on pharmaceuticals, so the claim that the ideal device is not yet available can only be interpreted as a challenge to hologram suppliers. Either holograms have failed to deliver what the pharma sector requires or hologram manufacturers have not succeeded in persuading their customers to use all the levels of security that a hologram can offer; that is first, second and third levels overt, covert and machine read. To implement covert and machine read requires additional investment by customers in training, reading tools and for machine read infrastructure. Ideal Sector The pharmaceutical sector is ideal for the introduction of such an infrastructure. Another call at the Global Forum was for increased harmonisation of authentication and inspection systems. In a sector which is as regulated and as controlled as this one, where all medicines (at least, the legitimate ones) are distributed through a controlled system in a willing partnership between manufacturers, distributors, retailers and governments, training and equipping those who handle the goods to examine the authentication device should be feasible. As should the introduction of a machine-read infrastructure, assuming that there is commonality of what is to be read. The call for greater harmonisation results from the heterogeneity in the sector at present, which makes inpsection and examination a harder task for all involved. At present each hologram supplier offers its own proprietary method of encoding and reading hidden data. It is impractical for a warehouse or pharmacist to be equipped with numerous hologram reading systems, each one required to read the differently encoded information on the holograms from each of the many manufacturers whose medicines they provide. Equally, government inspectors are not able to carry around numerous handheld devices. But as the well-established precedent of credit cards and bar-codes shows, distributors and retailers will equip themselves to read standardised codes if the equipment footprint, cost and training required is minimal and the compatibility is maximal. Can the hologram industry achieve this for the pharmaceutical sector? That is to say, will the hologram industry recognise that here is a cause where collaboration on the adoption of a common approach to encoding and decoding could offer the industry the opportunity to capture that market for many years to come? Because once established, any competing technique has not just to prove itself superior, but must also overcome the inevitable reluctance of a whole sector to change the way it does things. Huge Advantage The hologram industry starts with a huge advantage because holograms have an established customer base in the Pharma sector. And holograms are perceived by the public as a mark of authentication the public may not know how to examine a hologram but its presence gives a level of comfort. Yet if the industry takes no coherent action to work together, it will squander this advantage. The Pharma sector (manufacturers, regulators, even patients groups) is making a case for the ideal authentication device, without perhaps realising that what is actually needed is an authentication system. That system could be built around holograms but it could alternatively be built around other types of device. There are many alternatives all seeking to usurp holograms from their number one spot. Recently, RFID has made the running, in lobbying and PR terms at least, but other technologies taggants, magnetics, complex bar-codes and others are all looking for their ‘killer application and see th e pharma sector as ripe for their efforts. The pharma sector is giving mixed signals about the use of holograms. On one side, Pfizer, in its current generation of product authentication, is currently using colour shift inks instead of holograms as the basis for its solution; on the positive side, Malaysias Meditag uses a three-level hologram (overt, covert and machine-read) at the heart of a system of registration and inspection. Can the hologram industry not individual suppliers, but the industry working together persuade the whole pharmaceutical sector that Malaysias is the way forward, not Pfizers? The RFID industry successfully lobbied the US Food Drugs Administration anticounterfeit task force so that it has identified RFID as the best way forward, although it has left the door open for other technologies by not mandating the use of RFID. This is the example the hologram industry needs to follow, because it has to persuade governments, distributors and manufacturers that the pharma sector can continue to use or even, needs to use holograms at the heart of an integrated system of authentication. The prize is immense, because other market sectors would follow the pharmaceuticals sector. There is no consolation prize, because surrendering this market sector to an alternative technology would give an unavoidable signal to other market sectors. 010 HoloTouch Progress HoloTouchâ„ ¢ Inc, a development company based in Darien, Connecticut working in association with Atlantex Corp, has launched the BeamOne HoloTouch evaluation unit, a working demonstration of its noncontact control technique. HoloTouch was founded by R Douglas McPheters to exploit its patented process for projecting a real holographic image of a keypad or similar finger-tip control board such that passing a real item, such as a finger, through the image, activates the control (US Patent 6377238 see H N Vol 17 No 6). Atlantex specialises in helping bring new products to market, especially in the field of electronic controls and computer accessories . The BeamOne is a four-button box to issue instructions to a PC, to which it is connected by a USB cable. The holographic image of the buttons float about 4 (10 cm) above the BeamOne box and can be programmed to instruct the computer to perform the required functions. It is fully functional, priced at US$1995, but is characterised by Atlantex and HoloTouch as an evaluation device. Nonetheless, it has been chosen by readers of Control Engineering as ‘the most innovative human-machine interface featured in Control Engineering during the past year. McPheters identifies HoloTouch as suiting applications where non-contact is important, such as in a sterile environment, or where switches or buttons cannot be made rugged enough for the environment. The hologram image can also be larger than the keypad it mimics, making it suitable where the device is small or vision may require assistance, such as for sight impaired people or while driving a vehicle, where a quick glance at a small but ton can be dangerous. The hologram is also, of course, intrinsically illuminated, so it is useful for night time or dark environments. HoloTouch and Atlantex are looking for applications partners who will adapt the HoloTouch technique into their own control devices. www.HoloTouch.com HoloTouch Selected for FastTrack HoloTouchâ„ ¢ Inc, the company that has developed a holographic interface for contactless control devices, has been selected for Connecticut Technology Councils FastTrack scheme for promising high-technology start-ups. FastTrack is an advisory and matching programme that helps start-ups with innovative ideas and rapid growth potential to gain seed-stage capital and business planning input through the mobilisation of a network of investors, advisors, professional service providers and industry contacts. Commenting on the scheme, HoloTouch founder and president R Douglas McPheters said: ‘FastTrack offers potentially valuable assistance in connecting us with mentors and advisors and can promote our partnering with companies who see value in our innovative touchless, holographic actuation and control technology. The company has already partnered with Atlantex Corp to launch the BeamOne HoloTouch unit. This enables operators of control boards such as keypads to enter commands simply by passing a finger through holographic images that represent these commands and float in front of the device (see HN Vol 19, No 3) and is suited for applications where non-contact is important for operability of hygiene, including consumer electronics, kiosks, ATMs and medical equipment. HoloTouch and Atlantex have also announced that the BeamOne is now available with relay output, extending the technologys reach to electronic equipment controlled by programmable logic controllers (PLCs). BeamOne already offers communication with PCs through USB, serial and other ports. According to McPheters, this latest development means that the technology can now be used in a numerous industrial applications as well, such as factory floor equipment. McPheters will be presenting a paper on the HoloTouch technology at Holopack†¢ Holo-print 2005. Contact: www.holotouch.com 011 Holotek Doubles Sales and Profits Holotek Technologies Ltd, of Sanzao Zhuhai in China, has doubled its sales and profits in 2004 and is aiming to achieve at least 50% growth in 2005. Its 2003 audited sales of RMB103m ( ±US$12.5m) rose to RMB210M ( ±$25.5m) in 2004, with net profit climbing from RMB58m ( ±$7m) to RMB123.5m ( ±$15.2m), but note that the 2004 figures are not yet audited. Although the company was not liable to tax in its first years of operation (as a start-up in the Zhuhai Economic Zone), these margins of almost 60% make Holotek probably the most profitable holographic producer in the world, both by margin and in its dollar figure. 98% of these sales are for packaging, mainly for transfer metallising of cigarette liners and cartons; 85% is on OPP with the reminder on PET. Holotek has been through ownership changes since we first reported on the company (see HN Vol 17 No 6). It was set up by Fong Teng Technology of Taiwan, but government regulations limit the investment that can be put into a mai nland Chinese company from Taiwan. FT has accordingly sold its interest to four private shareholders, including the CEO Mark Chiang (as a minority owner), and Holotek operates as a subsidiary of Aimrich which is registered in Samoa. The company has also divested its former 49% holding in Yong Feng Tian Technology, a Shenzhen company that produces cigarette packaging materials. All these changes mean Holotek has also postponed its plans to float on the Hong Kong stock exchange. It had originally stated its aim was to float this year with a market capitalisation of US$150m, but it is now aiming for floatation in 2008 with a Changes in Holography Changes in Holography 001 Looking Back, Moving Forward How was 2004 for you? For the industry as a whole, reviewing the developments that we covered last year in Holography News, we can conclude that it was a good year for most, with many positive developments that set the scene for 2005 and beyond, but with sufficient clouds on the horizon to prevent any complacency. In terms of markets, in the high security arena the growth of holograms on banknotes continues apace (see page 3) and this will continue to be key market notwithstanding the recent news that the new $100 and other denominations will not, in all likelihood, include a holographic feature. In other high security markets, passports took something of a back seat, for holograms at least not because of technology concerns but because of the current pre-occupation with biometrics. But elsewhere in document protection, AAMVAs specification of holograms on all US driving licences was a significant boost for the industry, while the tax stamp market continues provide significant high volume opportunities for suppliers. There were few major developments in brand protection although the use of holograms as the prime authentication feature on a new labelling program for pharmaceutical products in Malaysia, and the Olympics 2004 merchandising program demonstrated the continuing success of hologram s in these areas. On the downside, the FDAs controversial decision to adopt RFID-based track and trace as the solution to product safety and supply chain management for pharmaceuticals in the US could have unwelcome consequences for the industry should drug regulatory authorities elsewhere in the world follow its example. In packaging, meanwhile, as the Stock watch article in this issue (see page 6) points out, it is barely possible to go out nowadays without seeing holography embellishing shop shelves on all manner of goods from luxury high end to everyday items. Innovation and Development On the technology front, holography continued to demonstrate its inherent capacity for innovation and development. The integration of holograms with other technologies for enhanced security and functionality continued apace examples including Schreiners KeySecure technology, Securiketts Authentikett labels, combined hologram/DNA/RFID labels from ADNAS and Holomex and enhancements to teas scribos Holospot system (see page 8) to name but a few. In the banknote market, De La Rue, Louisenthal and Kurz all launched new security features during 2004 based on combinations of substrate, thread and foil technology. In terms of production, Newmec and Gidue both entered the market with foil applications systems, General Vacuum launched its new compact metalliser while Spatial Imagings new Lightspeed digital hologram printer marked the beginning of new era in large format hologram origination. Aside from the developments in the ‘conventional market for authentication and decorative devices, holography is also beginning to demonstrate its potential for use as a tool as well as a feature. Examples of this potential include Smart Holograms development of reflection holograms as medical diagnostic devices and holographic data storage systems from Optware. Publicly-listed companies were covered in detail in the December issue of Holography News. But there was news from many other qua rters as well, including the expansion plans announced by ABNH, ITW Covid, AFC and Holoshape, and AET Films move into wide embossing on the packaging front. Louisenthal, a major player in the banknote industry, revealed that it now offers full-scale hologram production, including origination, while its former strategic partner in foils, Hueck Folien, joined the ranks of banknote suppliers with its first order for stripes for the Thai currency, signalling a potentially significant new entrant to the market. Its arrival was partially offset by AOTs decision to abandon banknote foils, while the bankruptcy of another high security supplier, Mantegazza, was staved off by its acquisition by Italian security papermaker Fabriano. Outside of the traditional industry centres of Western Europe and North America, the Far East, India and Eastern Europe and the CIS countries continue to play an increasingly important role not just as markets for western companies but as major centres of developm ent in their own right. Russia, a hotbed of scientific innovation, held its first regional conference this year; the commitment amongst Indian companies to quality and industry standards is an inspiration to us all, while all eyes are currently on China, the location for the 2005 Holo-pack†¢Holo-print which will provide the first opportunity for many western hologram companies to witness the strength and scope of this massive market. 2004s Downside So much for the positive. On the downside, RFID continues to position itself, and be viewed in some quarters, as the ‘silver bullet antidote to counterfeiting and diversion, new technologies such as Nanoventions claim their superiority over diffractive features and high quality counterfeit holograms have been discovered on currency notably the euro. The latter, in particular, is leading to a perceptible sense of disenchantment with holograms in terms of their claimed security benefits, technology proliferation and lax standard s amongst suppliers. This topic has been covered exhaustively in recent issues of Holography News and was one of the main topics for discussion at the recent Holo-pack†¢Holo-print conference in Prague, a positive outcome of which was the openness of debate and willingness amongst industry participants to work collectively to address the real issues that are causing concern and counter the misperceptions behind them. All in all, not a bad year for the industry. Provided the concerns leading to disenchantment in some sectors continues to be recognised and addressed with appropriate measures, and provided hologram companies continue to invest in the new products and techniques that form the lifeblood and future of this industry, 2005 could be even better. 002 A Watershed Year for the IHMA In his Chairmans report to the Annual General Meeting of the International Hologram Manufacturers Association, Hugues Souparis identified the launch of the Secure Hologram Producer Certification Scheme as a watershed for the Association (se HN Vol 18 No 3). This Scheme, run in co-operation with Intergraf, should make a significant contribution to improving procedures in the secure hologram field, and help to raise customer awareness of the need to source secure holograms from a qualified secure producer. Souparis company, Hologram Industries, was the first to be certified, but several others have now applied. Another important development during the year had been the negotiations with the Hologram Manufacturers Association of India (HoMAI), aimed at building a strong relationship between the two associations and serving as a model for the IHMAs relationship with other regional or national hologram associations. An important part of the planned relationship was that the IHMAs Hologram Image Register and HoMAIs Hologram Registry would be linked so that all searches for a hologram match on either database would cover both databases, improving the likelihood of identifying matches which resulted from attempts to source illicit copies of a hologram already in use. He reported that Despite the news that the US Bureau of Engraving and Printing is casting its net wider for security features (see page 1), banknotes continue to be a good market for the holography industry. A number of new banknotes have been introduced during 2004, including two major currencies the new Canadian dollar series which features a stripe and the two higher denominations of the newly-designed Japanese yen, each with a patch. Kurz was the supplier for both, the latter understood to be the largest single hologram order for banknotes in the industry. Other currencies that have introduced holograms to all or most of their the Board was in discussion with the China AntiCounterfeiting Technology As sociation (CATA) with a view to CATA establishing a hologram section, and that the IHMA was also in preliminary discussions with Russian producers interested in an industry organisation there. Souparis also reminded members of IHMAs links with Interpol and other international and national police organisations, saying that he hoped to build on these contacts in the coming year. New Board Members In the elections at the AGM, Souparis was re-elected Chairman a post he can hold for another two years. Wilfried Schipper (Hologram Company Rako) was elected as the European representative on the Board, with Alkis Lembessis (Cavomit and Taurus) as his deputy; Umendra Gupta (Holostik India) was re-elected as Asian representative, with Khalid Khanani (Metatex) as deputy. Randy James (Pacific Holographics) was elected as deputy North American representative and since the AGM the Board has co-opted John Halotek (ITW Covid) as the North American representative, there being no accepted nomination at the meeting. Alex Goncharsky (Computer Holography Centre, Moscow) and Ken Traub (ABNH) remain on the board for a second and fourth year respectively. Spreading the Word In addition to the objectives above, a key task for the IHMA in 2005 and thereafter will be to promote the positive benefits of holograms, particularly as authentication devices, as a counter to disenchantment with the technology in certain quarters, notably some parts of the high security sector. A proactive PR campaign, a greater presence at industry conferences, an improved website as a communications tool both for members and users, and a drive to increase the membership and the visibility of the IHMA are all currently underway. The hologram industry is one of the few in the authentication sector to have its own association and the IHMA is committed to building on this position and the strengths that a collective voice can provide for hologram companies. Contact: www.IHMA.org. 003 General Vacuums New Compact Metalliser (Pg # 5) General Vacuum, manufacturer of vacuum metallising equipment, unveiled further details of its new compact Holosecâ„ ¢ metalliser (see HN Vol 18 No 2) at the recent Holo-pack†¢Holo-print conference in Prague. Vacuum metallisers have until now been supplied with production widths of 800-3000m, limiting their use both financially and for production purposes among small and narrow-web hologram producers and forcing these to buy in their film and foil pre-metallised from wide web suppliers. The Holosec was designed to fill this niche and enable narrow-web producers to bring metallising in-house, thereby increasing their security of production and enabling them to take advantage of the specialised treatments the system offers. The Holosec combines the vacuum chamber, unwind and rewind units, plasma pre-treatment, demetallization and evaporation source within one compact unit with a footprint of 2m x 3m. In addition to the conventional aluminium used for holographic films and foils, it can coat silicon oxide, chrome, silver and copper and zinc sulphide for high refractive index films. It also offers pattern demetallisation with in-line registration and plasma pre-treatment that enhances the sur face energy of the films to improve adhesion and hence quality. The run rate varies from 10m to a maximum of 200m per minute. General Vacuum, formerly Valmet and now part of the Bobst Group, declined to give prices for the Holosec, stating that these depend on specification. But it can assumed that they will be considerably lower than the prices for wide web systems. When questioned at Holopack.†¢ Holo-print about the risks of spreading low-cost secure hologram production technology in the market, Dr Nadir Ahmed, who gave the presentation on behalf of his former company, commented that the company would check the legitimacy of customers before supply. To date, two machines have been sold with other orders in the pipeline for early 2005. Contact: Andy Jack, General Vacuum Equipment. Tel: +44 1706 622442; [emailprotected] 004 Menzel Vision System for Web Guiding Menzel, a German company specialising in machinery for finishing and inspection machines for textiles, expanded into similar equipment for the plastic films industry in the late 1960s, and at Holopack†¢ Holo-print exhibited a machine vision system for control of web handling machines for holographic films. The system keeps web lines in register to improve the accuracy and quality of slitting, winding/re-winding, stamping and other hologram finishing processes. Based on the companys experience building textile and film web guiding systems, the hologram guiding system can be set to read the edge of the hologram film or a specific part of the pattern in the hologram the camera scans across the width of the film to record the edge position, the registration mark position or the position of a specified image element. Once programmed, it feeds the image data to a sensor and a controller, which in turn adjusts the web guides to maintain the position of the web. The Menzel vision system for holographic film costs around â‚ ¬17- 20,000, depending on the configuration required. Contact: www.menzel.net. 005 Optical Document Security The third edition of the reference book Optical Document Security is now available from publishers Artech House. Written by Rudolf van Renesse, an expert in the field and editor and co-author of the two previous editions (published in 1994 and 1998 respectively), the book provides a comprehensive and cohesive treatment of all aspects of optical document security, according to its publishers. The books contents have been substantially updated and revised from the previous edition, and expanded to include coverage of additional security features and evaluation. The introduction on the theory of colours is followed by chapters on light interference and diffraction, substrate-based security, printing inks and printing techniques, printed security patterns (including screen decoded images and digital watermarks), diffractive- and interference-based security features, security design and evaluation and an introduction to biometrics. The emphasis is on both the physics of security features and their value in resisting counterfeiting, while the chapter evaluating security design looks at the human factors of first line document inspection. The books 350 pages contain over 270 black and white illustrations, including live security documents, and an appendix with samples of important security features. In addition, a CD-ROM is included which contains all illustrations of the book in full-colour. Author Rudolf van Renesse was senior research engineer in the Optics Department of TNO Institute of Applied Physics in The Netherlands and is now an independent consultant on document security for government departments and banking and financial institutions. He has extensive experience in the areas of holography, optical inspection techniques, and the theory of colors and document security, and is the author of more than 80 publications in these areas, as well as a contributor to Holography News and its sister publications Authentication News and Currency News. Optical Document Security is available at the discounted price  £72/$118 from Artech House www.artech-house.com 006 Display Holography on the Rise Photopolymer is making progress winning projects that perhaps embossed hologram producers might have expected to supply We feel for Nick Hardy and Valerie Love of OpGraphics, the British company that has listed its DuPont photopolymer hologram production equipment for sale on eBay. Op has been producing display holograms for the gift and promotional trade since 1983, originally on Agfa silver halide films, then in the 1990s Nick Hardy started working with DuPonts holographic photopolymer, partly because Agfa ceased production of its holographic films, partly because the photopolymer reflection holograms had lower noise and were more light efficient. Unfortunately, when DuPont Authentication Systems was established as a joint venture with Label Systems Inc, the company decided to restrict the distribution of its unexposed photopolymer film to authorised security hologram producers. Op were among the hologram producers which were given notice of a cessation of supply. They tried to fight this under competition law in the UK, but despite their significant investment in DuPonts production equipment and the time to perfect their processes, this was to no avail. The result: holographic production kit being offered on eBay. The Year of Photopolymer? The timing could not be more poignant as there appears to be an upsurge of interest in photopolymer holograms could 2005 be the year of photopolymer? The year has started well for DAS with NASCARs announcement of its licensed product authentication label, a numbered photopolymer reflection hologram (see page 4). To date, the North American sports licensing authentication projects have been dominated by embossed holograms. NASCAR (the most popular motor sport organisation in North America) may not rival the big national sporting leagues in popularity, but big race meetings such as Daytona and Indianapolis attract large crowds of eager souvenir hunters. Last year, DAS released its izonâ„ ¢ advanced photopolymer holograms, offering instant holo portraits on the film, making it particularly suitable for ID documents. And across the Pacific, Dai Nippon and Nippon Paint Co announced that Teikoku Piston Ring Co had become the first major customer for authentication holograms on Secure I mageâ„ ¢ hot-stampable photopolymer. So photopolymer is making progress in the brand protection market, perhaps winning projects that embossed hologram producers might have expected to supply. Two announcements do not make a fully-fledged market, but do represent progress. Coming Full Circle And now, coming full circle, Liti Holographics has announced that it is shipping a new instant holographic film suitable for reflection holograms for the home and hobby market (see page 3). Meanwhile, silver halide display holograms remain a force in the marketplace. Slavich continues to find a market in Russia and beyond for its silver halide plates and films, and Colour Holographics, which took over the production and supply of HRT holographic plates, finds a steady if not spectacular market. The company is finding a ready market for its own large format co lour holograms, while other silver halide display hologram producers remain in steady production. The availability of compact LED lights which illuminate holograms at a very high quality, and the improved recognition by holographers that they have to deliver a complete, lit and framed installation, is boosting the readiness of display artists and interior designers to consider display holograms as a medium. As one who first got involved in holography because of the excitement of such 3D images, it is reassuring and somewhat surprising to see the continuing interest in full parallax holograms, complementing and supplementing the large volume market of embossed holograms. 007 Litis New Reflection Film Liti Holographics, which offers low cost portrait hologram kits selling for $99 (see HN Vol 18, No 9), has launched a new hologram film. According to the company, this film has all the ‘instant hologram qualities of its previous film but is now capable of making reflection as well as transmission holograms. The new film is red-sensitive, making it compatible with both the Litiholo and other hologram kits, as well as red laser diodes and even helium neon lasers. Contact: www.litiholo.com 008 Nigerias New Pharma Certificate NAFDAC, the Nigerian Food Drugs Agency, has introduced a new certificate to be issued to authorised imported and domestically produced pharmaceuticals. The new certificate is being produced by a security printer in the UK and includes a hologram among its security features. This follows participation by Dr Dora Akunyili, Director of NAFDAC in the first Global Forum on Pharmaceutical AntiCounterfeiting, where she made contact with possible suppliers among the exhibitors. 009 Pharmaceuticals: a Hologram Market Expanding or Threatened? At the time of writing, the 2nd Global Forum on Pharmaceutical AntiCounterfeiting has just finished in Paris, organised by Holography News publisher, Reconnaissance International. One of the themes to emerge during the course of the 21/2 day meeting was the importance of authentication of genuine products as part of the system to combat counterfeit medicines, heard from speakers from national drug regulatory agencies and from pharmaceutical manufacturers. Several of the speakers implied, but Dr Thomas Zimmer of Boehringer Ingelheim explicitly stated, that the ideal authentication device for pharmaceuticals is not yet available. As Dr Zimmer was speaking in his capacity as Chairman of the Anti-Counterfeit Group of the European Federation of the Pharmaceutical Industry Associations (EFPIA), his observations must be taken seriously by suppliers or aspiring suppliers of authentication products to the pharmaceutical sector. To date holograms have been the leading device used for overt authentication on pharmaceuticals, so the claim that the ideal device is not yet available can only be interpreted as a challenge to hologram suppliers. Either holograms have failed to deliver what the pharma sector requires or hologram manufacturers have not succeeded in persuading their customers to use all the levels of security that a hologram can offer; that is first, second and third levels overt, covert and machine read. To implement covert and machine read requires additional investment by customers in training, reading tools and for machine read infrastructure. Ideal Sector The pharmaceutical sector is ideal for the introduction of such an infrastructure. Another call at the Global Forum was for increased harmonisation of authentication and inspection systems. In a sector which is as regulated and as controlled as this one, where all medicines (at least, the legitimate ones) are distributed through a controlled system in a willing partnership between manufacturers, distributors, retailers and governments, training and equipping those who handle the goods to examine the authentication device should be feasible. As should the introduction of a machine-read infrastructure, assuming that there is commonality of what is to be read. The call for greater harmonisation results from the heterogeneity in the sector at present, which makes inpsection and examination a harder task for all involved. At present each hologram supplier offers its own proprietary method of encoding and reading hidden data. It is impractical for a warehouse or pharmacist to be equipped with numerous hologram reading systems, each one required to read the differently encoded information on the holograms from each of the many manufacturers whose medicines they provide. Equally, government inspectors are not able to carry around numerous handheld devices. But as the well-established precedent of credit cards and bar-codes shows, distributors and retailers will equip themselves to read standardised codes if the equipment footprint, cost and training required is minimal and the compatibility is maximal. Can the hologram industry achieve this for the pharmaceutical sector? That is to say, will the hologram industry recognise that here is a cause where collaboration on the adoption of a common approach to encoding and decoding could offer the industry the opportunity to capture that market for many years to come? Because once established, any competing technique has not just to prove itself superior, but must also overcome the inevitable reluctance of a whole sector to change the way it does things. Huge Advantage The hologram industry starts with a huge advantage because holograms have an established customer base in the Pharma sector. And holograms are perceived by the public as a mark of authentication the public may not know how to examine a hologram but its presence gives a level of comfort. Yet if the industry takes no coherent action to work together, it will squander this advantage. The Pharma sector (manufacturers, regulators, even patients groups) is making a case for the ideal authentication device, without perhaps realising that what is actually needed is an authentication system. That system could be built around holograms but it could alternatively be built around other types of device. There are many alternatives all seeking to usurp holograms from their number one spot. Recently, RFID has made the running, in lobbying and PR terms at least, but other technologies taggants, magnetics, complex bar-codes and others are all looking for their ‘killer application and see th e pharma sector as ripe for their efforts. The pharma sector is giving mixed signals about the use of holograms. On one side, Pfizer, in its current generation of product authentication, is currently using colour shift inks instead of holograms as the basis for its solution; on the positive side, Malaysias Meditag uses a three-level hologram (overt, covert and machine-read) at the heart of a system of registration and inspection. Can the hologram industry not individual suppliers, but the industry working together persuade the whole pharmaceutical sector that Malaysias is the way forward, not Pfizers? The RFID industry successfully lobbied the US Food Drugs Administration anticounterfeit task force so that it has identified RFID as the best way forward, although it has left the door open for other technologies by not mandating the use of RFID. This is the example the hologram industry needs to follow, because it has to persuade governments, distributors and manufacturers that the pharma sector can continue to use or even, needs to use holograms at the heart of an integrated system of authentication. The prize is immense, because other market sectors would follow the pharmaceuticals sector. There is no consolation prize, because surrendering this market sector to an alternative technology would give an unavoidable signal to other market sectors. 010 HoloTouch Progress HoloTouchâ„ ¢ Inc, a development company based in Darien, Connecticut working in association with Atlantex Corp, has launched the BeamOne HoloTouch evaluation unit, a working demonstration of its noncontact control technique. HoloTouch was founded by R Douglas McPheters to exploit its patented process for projecting a real holographic image of a keypad or similar finger-tip control board such that passing a real item, such as a finger, through the image, activates the control (US Patent 6377238 see H N Vol 17 No 6). Atlantex specialises in helping bring new products to market, especially in the field of electronic controls and computer accessories . The BeamOne is a four-button box to issue instructions to a PC, to which it is connected by a USB cable. The holographic image of the buttons float about 4 (10 cm) above the BeamOne box and can be programmed to instruct the computer to perform the required functions. It is fully functional, priced at US$1995, but is characterised by Atlantex and HoloTouch as an evaluation device. Nonetheless, it has been chosen by readers of Control Engineering as ‘the most innovative human-machine interface featured in Control Engineering during the past year. McPheters identifies HoloTouch as suiting applications where non-contact is important, such as in a sterile environment, or where switches or buttons cannot be made rugged enough for the environment. The hologram image can also be larger than the keypad it mimics, making it suitable where the device is small or vision may require assistance, such as for sight impaired people or while driving a vehicle, where a quick glance at a small but ton can be dangerous. The hologram is also, of course, intrinsically illuminated, so it is useful for night time or dark environments. HoloTouch and Atlantex are looking for applications partners who will adapt the HoloTouch technique into their own control devices. www.HoloTouch.com HoloTouch Selected for FastTrack HoloTouchâ„ ¢ Inc, the company that has developed a holographic interface for contactless control devices, has been selected for Connecticut Technology Councils FastTrack scheme for promising high-technology start-ups. FastTrack is an advisory and matching programme that helps start-ups with innovative ideas and rapid growth potential to gain seed-stage capital and business planning input through the mobilisation of a network of investors, advisors, professional service providers and industry contacts. Commenting on the scheme, HoloTouch founder and president R Douglas McPheters said: ‘FastTrack offers potentially valuable assistance in connecting us with mentors and advisors and can promote our partnering with companies who see value in our innovative touchless, holographic actuation and control technology. The company has already partnered with Atlantex Corp to launch the BeamOne HoloTouch unit. This enables operators of control boards such as keypads to enter commands simply by passing a finger through holographic images that represent these commands and float in front of the device (see HN Vol 19, No 3) and is suited for applications where non-contact is important for operability of hygiene, including consumer electronics, kiosks, ATMs and medical equipment. HoloTouch and Atlantex have also announced that the BeamOne is now available with relay output, extending the technologys reach to electronic equipment controlled by programmable logic controllers (PLCs). BeamOne already offers communication with PCs through USB, serial and other ports. According to McPheters, this latest development means that the technology can now be used in a numerous industrial applications as well, such as factory floor equipment. McPheters will be presenting a paper on the HoloTouch technology at Holopack†¢ Holo-print 2005. Contact: www.holotouch.com 011 Holotek Doubles Sales and Profits Holotek Technologies Ltd, of Sanzao Zhuhai in China, has doubled its sales and profits in 2004 and is aiming to achieve at least 50% growth in 2005. Its 2003 audited sales of RMB103m ( ±US$12.5m) rose to RMB210M ( ±$25.5m) in 2004, with net profit climbing from RMB58m ( ±$7m) to RMB123.5m ( ±$15.2m), but note that the 2004 figures are not yet audited. Although the company was not liable to tax in its first years of operation (as a start-up in the Zhuhai Economic Zone), these margins of almost 60% make Holotek probably the most profitable holographic producer in the world, both by margin and in its dollar figure. 98% of these sales are for packaging, mainly for transfer metallising of cigarette liners and cartons; 85% is on OPP with the reminder on PET. Holotek has been through ownership changes since we first reported on the company (see HN Vol 17 No 6). It was set up by Fong Teng Technology of Taiwan, but government regulations limit the investment that can be put into a mai nland Chinese company from Taiwan. FT has accordingly sold its interest to four private shareholders, including the CEO Mark Chiang (as a minority owner), and Holotek operates as a subsidiary of Aimrich which is registered in Samoa. The company has also divested its former 49% holding in Yong Feng Tian Technology, a Shenzhen company that produces cigarette packaging materials. All these changes mean Holotek has also postponed its plans to float on the Hong Kong stock exchange. It had originally stated its aim was to float this year with a market capitalisation of US$150m, but it is now aiming for floatation in 2008 with a

Virus-host Receptor Interactions in Biology

Virus-host Receptor Interactions in Biology Abstract Viruses are obligate intracellular parasites and, as such, must penetrate a suitable host cell in order to replicate their genomes and disseminate. Most viruses are limited to a specific set of cells or tissues in which they can successfully replicate, and this may be in one or more particular species. When viruses are able to bind a variety of cells, the pathogenesis and overall effect on the organism may differ. The main determinants of viral tropism differ between different virus families, but in order to take the first, and arguably most important step, in the infection of a host cell, the virus must attach via specific interactions between cell surface molecules and viral proteins. Enveloped viruses usually have proteins embedded in their envelope, assembled at the host cell surface prior to budding. In the case of some viruses (such as HIV-1), these may even consist of cellular proteins from the host cell itself. Non- enveloped viruses are usually internalized in some way and uncoated in an endosome in a pH-dependant manner. Many viruses require a number of cell surface receptors for cell entry, and it is this combination, added to other factors such as replication proteins, that determine whether or not a virus can penetrate and replicated within a certain cell. Introduction As obligate intracellular parasites, the life cycle of viruses depends on an intracellular replication phase and they are thus dependant on living cells. The first essential interaction a virus makes with a host cell is with a cell-surface receptor. A viral receptor may be defined as any cell surface component that mediates recognition of a cell and facilitates entry of the virus and subsequent infection. Receptors serve to ensure infection by overcoming repulsion between the virus and cell. (Baranowski, Flint, Jindrak, modern virol) Cellular receptors are generally proteins, although other types of receptor, such as carbohydrates, may be used (see table 1). These molecules are essential components of the cell or extracellular matrix and functions may include cell adhesion, signalling e.g. chemokine and growth factor receptors. (Baranowski 2003) While some viruses require only one receptor, binding to one cellular receptor alone may not be sufficient for initiation of infection for other viruses. Viruses may bind two or more receptors in sequence in order to initiate endocytosis or membrane fusion. For some viruses, the first contact with a cell is through a low-affinity interaction with a ubiquitous molecule, which allows the primary receptor-virus interaction to take place. The primary receptor is generally unique to certain cells and therefore partly defines the tropism of that particular virus, as cells are rendered susceptible to infection by a certain virus if the receptor required for attachment and entry is present. The primary attachment receptor may induce a conformational change in the viral envelope protein bound, to induce further interaction with the cell. (Modern Virology) A further interaction may then be required to initiate infection, performed by a coreceptor.The definition of the term coreceptor may sometimes be ambiguous, but generally, it is taken to be the molecule that induces fusion or penetration of a cell. This may be a further determinant of tropism, for example the interaction of HIV-1 Virus entry into a cell is the first step in the life0cycle of a virus; various mechanisms of viral cell enrty are shown in figure 1. The mechanism of entry varies between viruses, but all begin with the binding of a cellular receptor by a viral protein. Binding of a cellular receptor may induce endocytosis or formation of an endosome, the acidic environment of which induces uncoating; this may be dependent upon cellular proteins clathrin or caveolin. Enveloped viruses may require an acidic environment that will induce conformational changes in envelope proteins required to induce membrane fusion, while others, including the measles and HIV viruses, can fuse directly with the plasma membrane at neutral pH. (Baranowski) Fusion at the plasma membrane releases the nucelocapsid into the cytoplasm, where the virus can make its way to the nucleus or begin replication in the cytoplasm. The differences in these entry pathways are due to the nature of the molecular interactions between the vi ral components and target-cell receptors, for example, viruses that mimic the natural ligand of receptors for signalling molecules interefere with their signalling to promote viral entry into the cell and spread of infection. (Bomsell) Conformational changes resulting from the binding of a primary receptor that allow the binding of a fusion receptor are a common mechanism among various types of virus, including influenza and HIV type 1, examples and brief description. Similar to Influenza . Multiple receptors could be coreceptors and act together either to modulate each other or to contribute complementary functions. Alternatively, the receptors might act sequentially. Binding of the virus to the first receptor could cause changes in the virus or host that are necessary before the second receptor can bind (50). For those viruses in fluids with flow, such as blood or respiratory secretions, the initial binding must be able to effect rapid docking of the virus to its host cell. (Haywood) As previously stated, some viruses recognise more than one cellular receptor. The same receptor may also be used by more than one type of virus. (see table 1) Often, these are highly abundant in many tissues, for example, heparan sulfate can serve as a receptor for many viruses, including Human immunodefiecieny virus, Hepatitis C and Dengue Virus and as a co-receptor for Herpesviruses (excluding EBV). (ODonnel) CAR, acts as a receptor for both coxsackie and adenoviruses. (Schneider) Table 1 illustrates the diversity of cell surface molecules which viruses have adapted to recognise. Some viruses use more than one type of molecule as a primary receptor e.g. reoviruses bind to the beta-adrenergic receptor as well as NAN. (Flint) While the presence of certain receptors on host cells is vital to initiate infection, these interactions are not always sufficient to explain all aspects of cell, tissue and species tropism. (Flint)(Haywood, Schneider) Binding of a viral protein to a cell surface receptor does not necessarily mean a productive infection will follow, since a co-receptor may be absent or functional domains of the receptor may be blocked. (Baranowski) Absence of specific cytoplasmic or nuclear molecules may hinder the replication of some viruses, despite their permissivity. However, even a non-productive infection may induce pathogenic effects, for example, binding to specific receptor may induce the secretion of cytokines. (Schneider) A virus generally cannot infect a cell successfully in the absence of its specific receptor, so the distribution around the body of the receptor will act as a restriction on the range of tissues that can be infected and hence on the number of systems in the body where sig ns and symptoms of infection might be experienced. (Flint) In the true sense of the word, Tropism refers to the specific cells a particular virus is able to replicate in, although the use of receptor by a virus is increasingly a valid definition in the field of virology. Additional factors the cause viral tropism will not be considered in the context of this essay, although they may be mentioned briefly where relevant, since the focus of this review is the link between specific receptor usage and virus tropism and pathogenesis. (Kuhmann) The primary topics explored here are the virus-receptor interactions with cells that allow viruses to enter cells and initiate infection and how this relates to the tropism of the virus at a cellular and organismal level. I am to demonstrate how viral attachment and entry is often a complicated multi-step process, sometimes requiring many different cell and virus molecules. The viruses largely used to illustrate these points, Human Immunodeficiency Virus type 1 (HIV-1), Influenza A and Herpes Simplex Virus type 1 (HSV-1) are human viruses of medical significance, but the tropism of these particular viruses in other animals, along with other viruses specific to other animals will be discussed where relevant. The structure and genomic organisation of these viruses is irrelevant and is only discussed where it relates to the glycoproteins that interact with cellular receptors. Viruses of plants, fungi and bacteria are not discussed The presence on the cell surface of a protein that has been identified as the receptor for a given virus may not be sufficient for a productive viral infection, and there may be multiple mechanisms behind such restrictions: functional domains of the receptor may be blocked in some cellular context, additional proteins (or other cofactors) may be needed, or cells may exhibit impediments for completion of the infection cycle, despite an initial successful interaction with a functional receptor. HSV- Demonstrates how viruses may use a large number of viral proteins and receptors to bind and enter specific cells. (Hayashi and Yoon) and how the interactions are a complex multi-step process. Influenza multiple steps. binds many cell types Tropism is dependent on other receptors and interactions. Of the many examples, the interaction of  the human influenza A virus hemagglutinin  with N-acetylneuraminic acid, and the ensuing  conformational alterations involved  in pH-dependent membrane fusion, are one  of the best characterized at the structural  and functional levels (11) (Baranowski 2001)  example of proteolytic cleavage to aid spread and pathogenesis. Conformational change required for fusion HIV A well-documented case of use of multiple receptos is that of HIV-1 viruses and related viruses. Illustrates how a virus may use multiple coreceptors to mediate entry to different types of cells and thus influence the tropism of this virus. Uses some of the same receptors as other viruses (parallels between HIV, HSV and influenza) Multi-step process The interaction of the virion with the attachment receptor leads to the first conformational changes in the envelope proteins. This step enables the interaction with co-receptors, or entry mediators and further conformational changes at the plasma membrane. In enveloped viruses (top), this may deliver the energy for the direct fusion of the viral envelope and cellular membrane. Some enveloped and non-enveloped viruses require the low pH in acidic endosomes to induce this conformational change. Enveloped viruses may require the low pH to induce membrane fusion (centre). These mechanisms lead to the release and possibly uncoating of the virus genome, and the initiation of the virus replication cycle. Role of Viral Receptor Destruction While non-enveloped viruses typically undergo relase through cytolysis. Influenza and HIV-1 Viruses also demonstrate the importance of receptor-destroying activity on the infectivity of some viruses. This is imperative for the efficient release and cell-cell spread of the virus by preventing the glycoproteins on the newly-emerged virus from binding to the host cell receptors. It is also important for preventing superinfection of cells by the same or different viruses utilising the same receptor, which may result in cell death. The efficient budding and release of Influenza A virus from the host cell relies on the removal of Sialic Acid residues by Neuraminidase. In contract, the HIV-1 virus gp120 envelope glycoprotein downregulates the CD4 receptor after infection of monocytes, by stimulating TNF-ÃŽÂ ± production. Other cellular mechanisms contribute to down-modulation of CD4, including the gene product Nef, which causes CD4 internalisation respectively. The precursor of gp120 and gp41, gp160, has also been found to bind CD4 intracellularly in the presence of viral protein Vpu, resulting in retention of CD4 in the Endoplasmic Rectilium. Enveloped particles leave the infected cell inconspicuously  by budding and secretion. Nonenveloped viruses  are usually thought to undergo release through cell lysis,  but some may escape by secretory mechanisms after  budding into membrane bound compartments and then  losing their membrane (Altenburg et al., 1980). Others  may subvert cellular autophagy pathways to gain access  to exocytic organelles (Jackson et al., 2005).  (Marsh)

Pro Immigration in the United States Essay -- Pros of Immigration, Immi

One of our nation's biggest problems if you would call it a problem is Immigration. I am writing this to inform my readers or in this case reader why immigration should be legal. I have based my research on three things, economy, Social Security, and freedom of life. I hope this essay will help you see a different perspective of immigration and what it can do for our country. Immigration has been going on in America since the seventeenth century when the English established settlements on Plymouth and Jamestown, which were originally the Native Americans. Notice where I?m going with this? No, ok, read on. Most of the Immigrants were European, until the passage of the Immigration Act was abolished in1965. Approximately one million Immigrants enter the US each year, and about 500,000 come in illegally. (Duignan). Lawmakers have attempted to revise immigration policies and crack down on illegal immigration in order to increase national security ever since 9/11. In 2007, President Bush decided that the best way to stop illegal immigration was to build a wall in-between the US, Mexico boarder. (Mankiller). 1798, a series of four laws passed by a Federalist-controlled Congress in anticipation of war with France during the administration of John Adams. Designed to restrict the pro-French and antiwar activities of the Jeffersonian Republicans, three of the laws d ealt with alien foreigners and one with sedition criticism of government officials and policy. Under the Alien Enemies Act (never repealed but amended) the president was authorized to imprison or deport citizens of enemy nations. The Alien Friends Act never enforced and expired in 1800 permitted deportation of citizens of friendly nations. The Naturalization Act repealed i... ...eing what can they do they have to get help fast but they don?t have money, well they need to get it some where. As a result they come to America, fast and they don?t get a green card, so we blame them for coming in to the country illegally. Just one of the reasons why immigration should be legal. I hope that this essay has taught you that Immigration isn?t awful, but that is good on the economy and some people?s wallets too. As I said in my opening paragraph if you don?t like immigration then remember this never I mean, never go on a trip to Mexico, Europe, Asia and so on because you would be the biggest hypocrites alive. Don?t say no to immigration because if you do they will keep coming, and coming, and coming, just kidding but I beg you remember Immigrants are just like you and me just with a different skin color (maybe) and a diverse language.

Time Management Essay -- Business Management Studies

Time Management The largest percentage of my time went into sleeping which isn’t a surprise, however tracking how I used my time made it obvious that further time management was needed to achieve my maximum potential. Such improvements would be to the undesirable categories: Structured and Un-structured leisure, a decrease by half the amount of hours used by these categories would assist my private studies and improve my overall academic performance. This should lead to a third of my time into travelling, eating, class contact, structured and un-structured leisure. And another third into private study and finally the last third into sleeping. Trying this new arrangement of time keeping provided to be a positive outcome in my day to day activities as it provided a strong backbone to my time management. In general, the hours used by the other categories are acceptable to maintain some balance and relaxation for the mind and body to sustain motivation and some social life. Overall reflection on personal strengths and weaknesses re time management based on evidence in my diary. The f...

Ode To The West Wind :: essays research papers

" Ode to the West Wind" was written by Percy Bysshe Shelley shortly before his death in 1822. Shelley spent the majority of his life in England where he was born to an upper class family. He attended Eton for his primary education and Oxford University until he was expelled for the publication of The Necessity of Atheism. Shortly after being expelled, Shelley married a commoner named Harriet Westbrook , which upset his family because of his wife’s low social standing. The marriage was short lived and Shelley quickly fell in love with Mary Godwin. Shelley continued writing throughout his life and his most notable works include "Ozamandias", "Laon and Cythna", and "Rosalind and Helen". Mary Shelley, Shelley’s wife who was also involved in literature, wrote Frankenstein. In 1822 Shelley drowned in a boating accident in the Gulf of Spieza. Shelly is mainly noted as the most passionate of the Romantic writers and for his usage of expe rimental styles in poetry. "Ode to the West Wind" was written by Shelley on a day when the weather was unpredictable and windy, the poem reflects the mood of the weather and expresses Shelley’s desire for creativeness and intellect. The first section of the poem focuses on the description of the colorful autumn leaves being stirred by the wind. The line " Wild Spirit, which art moving everywhere; Destroyer and preserver.." shows the relationship between Shelley’s desire to create and nature’s force. The second section of the poem tells about the clouds in the sky that are forewarning " the locks of the approaching storm". The fierce storm clouds represent Shelley’s frustration in his lack of original ideas. The third section relates the winds effect on the waves in the sea, which Shelley describes as ".. Grey with fear and tremble and despoil themselves†¦". In the fourth section of the poem Shelley shows his desire to be the autumn leaves, tempest clouds, and turbulent waves so that he to can be effected by the wind and nature the way the objects are.

Norwegian cruise line

In the 1980s, we saw an entertaining TV serial, â€Å"The Love Boat†, that shows us how beautiful the yacht is and what romance the passenger might have. In addition, almost a century ago, in 1912, we also witness that the Titanic, the biggest passenger ship in the beginning of 20th century sank during the journey between Paris and New York, in which 1,503 people lost their lives. From the two stories above, we learn that yacht or cruise line have been in the business for decades.Their target markets, as their luxurious ships suggest, are those who enjoy a journey in the sea and are willing to pay a considerably high price for the comfort. To meet such customers’ demands, the cruise line owner should provide a first-class service including the workers, foods and beverages, entertainments, and the cruise line itself. According to one report, the cruise line industry is a fifteen billion dollar worldwide business and it continues to grow at a rapid pace. Between January 2 001 and December 2005, the cruising industry adds their fleet with over fifty ships.While there are tens to hundreds cruising companies, in this paper, we will only focus the discussion on Norwegian Cruise Lines (NCL). Concerning the NCL, we will discuss about background of NCL, its offerings and differentiation strategies, global cruise market, pricing competition, competitors, and financial analysis. At the end, we will provide conclusion that describe the competitiveness of Norwegian Cruise Line in the cruising industry. 2. Norwegian Cruise Line.2. 1 Company Background Norwegian Cruise Line (NCL) is a 40-year old cruse line that originates from Miami, Florida in the U. S. Unlike other cruise line companies, NCL asserts that they offer distinctive services that guests/customers would not get from other cruise line companies. The so-called freestyle cruise line becomes the company’s tag line and perceived quality. The company’s business principle is to encourage innov ation in all aspects of cruise line services. That principle guides the company to record several awards and ‘the first company’ records in some aspects as following: ? The First Caribbean cruise ? Provide the First Internet cafe at sea.The First cruise line that has children's programs ? The First. cruise line to provide Freestyle Cruising ? The first cruise line that has WiFi connection ? Provide the first bowling alley at sea (NCL Corporation, 2007 – Our Company) 2. 2 Offerings and Differentiation strategies In order to keep alive in Cruise industry that has hundreds of players (cruise lines), a company may have to be perceived different from the rests. The situation also occurs for Norwegian Cruise line, a Miami (Florida – USA) cruise line that becomes one of well-known cruise line in the U. S. due to unique offerings.The unique offerings called Freestyle where guests can choose services they want. The freestyle services come in many forms such as free style dining where customers can select 13 different restaurants on a single ship, freestyle fund where guests can experience many kinds of entertainment and fun activities like bowling, jogging, hiking, surfing, and spa, to name a few (NCL Corporation, 2007 – freestyle) 2. 3 Global Cruise Market Hospitality industry is a business dealing with the provisions of food, beverages, and accommodation.According to one research, the industry is found to be the fastest growing industry in the world surpassing manufacturing and banking. In addition to airlines and restaurants business, one of branches in hospitality industry is Cruise Lines industry. Burke (2000) said that the cruise industry had maintained good performance within the past decades for two reasons: ? Cruise lines industry always show astonishing records in the number of passengers who sail the cruises.In 1998 alone, the number of passengers was over five million passengers with occupancy rates about 91 percent. ? The i ndustry continues maintains astounding growth rate about 10 percent per annum (Burke, 2000) The Cruise Industry started in 1960’s as a merely leisure cruising. During its first years, the industry grew enormously. By the 1980’s the larger cruise companies already constructing larger ships and the smaller companies trying to compete by acquiring second hand ships.In the 1990’s the cruise companies built â€Å"post-Panamax† ships, the ships weigh over 100. 000 tons and apparently too large to pas trough the Panama Canal. The largest market for the cruise industry is from the North America where Norwegian Cruise Line (NCL) exists. The other prospective market is European. In 2001, The North American Market consists of 7 million cruise passenger (72 % of world demand), 1. 9 million passenger originated from Europe (20 % of world demand) and 800. 000 passenger (8 % of world demand) are from Asia. For the last 5 years, the industry has grown faster than any oth er types of vocations.Continuous growth from years to come is expected to be 8 to 20 % of current market (‘Commission’, 2002). 2. 4 Pricing Strategies of of Norwegian Cruise Line (NCL) Competitors 2. 4. 1 Carnival Corporation (CCL) CCL is a company operating in the cruise ship industry. It provides cruise vacations leisure travels and sightseeing packages to customers worldwide. During 2004 the company has built 11 new ships. By February 2005, the company owned 77 cruise ships operating under 12 cruise brands (Eidam, 2004).

Why is education important in order to achieve the MDGs

The Millennium Development Goals ( MDGs ) are eight international development ends that were established after the 2000 Millennium Summit in which United Nations Member States and International Organisations consented to accomplish by the twelvemonth 2015 ( United Nations Millennium Development Goals, 2010 ) . The MDGs set clip edge marks in bettering societal and economic conditions in the universe ‘s hapless states, which advancement towards cut downing income poorness, hungriness, disease, deficiency of equal shelter and exclusion, while advancing gender equality, wellness, instruction and environmental sustainability. They besides embody basic human rights so that each individual on the planet has the right to wellness, instruction, shelter and security ( Ki-Moon, 2010 ) . Three major countries of Humanity are focused in the MDGs: First, reenforcing human capital by bettering substructure, and increasing societal, economic and political rights, specifically concentrating on increasing the basic criterions of life ( United Nations, 2006 ) ; Second, bettering substructure through increasing entree to safe imbibing H2O, energy and modern information communications engineering, magnifying farm end products through sustainable patterns, bettering transit substructure, and continuing the environment ; and eventually the societal, economic and political rights, including authorising adult females, cut downing force, increasing political voice, guaranting equal entree to public services, and increasing security of belongings rights. The ends are intended to increase an person ‘s human capablenesss and progress the agencies to a productive life ( United Nations, 2006 ) . As persons moving together we have the power to take action and influence the procedure of making the MDGs by 2015 ( End Poverty Millennium Campaign, 2010 ) . Education is of import in accomplishing these ends. A basic instruction of a good quality is necessary for developing an apprehension of the universe and the possibilities it provides, and for being able to work efficaciously within it. Without the cognition and assorted accomplishments developed through schooling and basic instruction plans, the chances for persons and the ability to move independently are greatly reduced ( UNESCO, 2010 ) . Escalating the motion towards instruction MDGs will take straight to an acceleration of many of the other MDGs ( 2010 MDG SUMMIT, 2010 ) . In this essay I will explicate why instruction is of import in order to accomplish each of the eight millenary development ends. The first end of the millenary development ends is to eliminate utmost poorness and hungriness. Poverty forces kids out of school displacing their instruction driving them into the low paid work force because parents can non afford to educate them. Haines & A ; Cassels ( 2004 ) explain that one twelvemonth of schooling can increase a individual ‘s net incomes by 10 % with each extra twelvemonth of schooling raising the mean one-year GDP by 0.37 % . Accessible instruction can assist feed an faultless rhythm of enhanced growing and an elevated decrease in poorness, helping the hapless and profiting society as a whole. Education provides people with the accomplishments and cognition they require in order to increase income and develop employment chances. By educating the hapless, adult females and vulnerable groups it opens doors to occupations and recognition and has the potency for economic growing. With rigorous Torahs on compulsory instruction the millenary development end to eliminate utmost poorness and hungriness should be accomplishable in the hereafter. The 2nd MDG is to accomplish cosmopolitan primary instruction. Every kid regardless of where they live deserve the right to an instruction. The Development Education online Depository ( 2010 ) province that cosmopolitan primary instruction involves come ining school at an appropriate age, come oning through the system and finishing a full rhythm of primary instruction. By eliminating primary school fees 1000000s of kids worldwide have the opportunity to derive literacy and numeracy accomplishments increasing the per centum of educated people in the universe, increases the chances for employment and a stable hereafter for many kids which in manus will assist in accomplishing the MDG of accomplishing cosmopolitan primary instruction. The 3rd MDG focuses on advancing gender equality and authorising adult females. Attaran ( 2005 ) province that there are 759 million people in the universe that can non read or compose, and of those people two-thirds are female. Females face many barriers to education in several states around the universe, runing from negative attitudes to the load of family work and distance to school. In order to right the balance instruction needs to be made a precedence, particular attempts such as using female instructors, back uping hapless households and doing the instruction system girl-friendly could assist in advancing gender equality and in authorising adult females. Severine & A ; Shahani ( 2009 ) claim that there is a strong correlativity between educating females and an addition in adult females ‘s net incomes, improved kid and household wellness and nutrition, an addition in school registration, protection against HIV infection, higher maternal and child life anticipation, reduced birthrate rates and delayed matrimony. Equal schooling for both male childs and misss is the foundation for development in accomplishing the MDG of advancing gender equality and authorising adult females. The 4th MDG purposes to cut down child mortality. Supplying instruction to girls provides a great opportunity of endurance to her kids in the hereafter. Severine & A ; Shahani ( 2009 ) claim that a female parent with secondary or higher instruction more than halves the hazard of kid mortality compared to a female parent with small or no instruction. As mentioned above there is a strong connexion between educating females and higher maternal and child life anticipation every bit good as betterments in kid and household wellness and nutrition, they are besides more likely to immunise their kids. Educating adult females, with at least primary instruction, the MDG of cut downing child mortality is more likely to be achieved. The 5th end purposes to better maternal wellness. Maternal instruction is one of the strongest counterpoisons to childbearing-related hazards ( United Nations, 2010 ) . By educating females it enables them to do improved wellness associated determinations, fewer female parents would decease and the MDG of bettering maternal wellness would hold a greater opportunity of being achieved. The 6th MDG intends to battle HIV/AIDS, malaria and other diseases. Education is the key to battling HIV/AIDS, malaria and many other diseases. Education establishments take a cardinal function in the bar of HIV and other catching diseases as they can make out to a big figure of people, promoting positive attitudes and behaviors supplying them with the cognition and accomplishments to cut down their opportunity of undertaking HIV. School wellness plans are besides ideal in supplying consciousness and hygiene patterns to assist contend malaria and other diseases. Haines & A ; Cassels ( 2004 ) province that adult females with an instruction higher than primary degree are five times more likely than literate adult females to be cognizant of and cognize about HIV/AIDS. Education offers an of import step of protection against HIV and other diseases. The MDG for cosmopolitan primary instruction is estimated to forestall 700, 000 new HIV infections each twelvemonth ( MDG Monitor, 2007 ) . It is claimed that instruction reduces the exposure of misss, and each twelvemonth of schooling offers greater protective benefits. Education is the best vaccinum against HIV and Aids and other diseases it is besides the most cost effectual manner to accomplish the MDG of battling HIV/AIDS, malaria and other diseases. The 7th MDG is directed at guaranting environmental sustainability. Education for sustainable development ( ESD ) can assist us to populate sustainably. ESD is defined by UNESCO as the purposes to assist people to develop the attitudes, accomplishments and cognition to do informed determinations for the benefit of themselves and others, now and in the hereafter, and to move upon these determinations. By supplying instruction for environmental sustainability it besides educates pupils on cardinal issues including poorness decrease, sustainable supports, planetary heating and clime alteration, gender equality, corporate societal duty and the protection of autochthonal civilizations ( TeachMDGs, 2010 ) ESD will let persons to do determinations that meet the demands of the present without compromising those of future coevalss. Education is indispensable for guaranting environmental sustainability. The 8th and concluding millenary development end is directed at developing planetary partnerships for development. Developing states financially can non supply cosmopolitan primary instruction for free to their people. Therefore a planetary partnership is needed to make full the fiscal spread for instruction so that globally the education-related development ends can be achieved. And if underdeveloped states make instruction a precedence they can so in bend hike their economic system, which can assist to accomplish all of the millenary development ends. Teaching and larning in schools should take to heighten accomplishments, cognition and behavior related to the millenary development ends. Schools should be after their course of study so that content covered increases the impact that instruction has on the MDGs. Such as, in order to battle child mortality and to change female authorization, course of study on cleanliness, sanitation, and steps to minimise contagious diseases. In the instance of environmental sustainability the school should include plans such as the demand to conserve H2O and trees. To better the nutritionary position of the pupils the school can present meal plans to guarantee the pupils have atleast one nutritionary repast each twenty-four hours. Schools can besides advance gender equality by the different functions that school leaders take. Positive behavior aimed at accomplishing the MDGs can be learned and reinforced throughout instruction. By presenting grownup instruction and literacy plans for both work forces and adult females can supply chances for employment, bettering labour productiveness and presenting plans such as H2O and sanitation. The impact of grownup instruction for adult females can ensue in lower kid mortality rates and higher degrees of maternal wellness. With the completion of secondary instruction adult females are more likely to seek out prenatal attention and better medical intervention, are more likely to direct their kids to school, and have greater economic chances that will relieve poorness and hungriness. All in all grownup instruction in occupational and life accomplishments will positively impact the millenary development ends. 2010 should non be the beginning of the ‘new and unsure ‘ journey towards the millenary development ends, instead it should be the ‘refueling ‘ point on this ocean trip that has been traveling on for the past 10 old ages. The following five old ages complete the journey in accomplishing the MDGs by 2015. With the execution of the millenary development ends in school course of studies globally the program to make the finish should be accomplishable.ResourcesAttaran, A. ( 2005 ) . An Immeasurable Crisis? A Criticism of the Millenium Development Goals and Why they can non be Measured. PLoS Medicine 2 ( 10 ) 318. Development Education on-line Depository. ( 2010 ) . Making Global Connections through Education. Retrieved from hypertext transfer protocol: //www.developmenteducation.info// Haines, A. & A ; Cassels, A. ( 2004 ) . Can the Millennium Development Goals Be Attained? British Medical Journal, 329 ( 7462 ) 394-397. MDG Monitor. ( 2007 ) . Quick Facts. Retrieved from hypertext transfer protocol: //www.mdgmonitor.org/country_progress.cfm? c=BEN & A ; cadmium Moon, K. ( 2010 ) . Millennium Goals. Retrieved from hypertext transfer protocol: //www.un.org/millenniumgoals/bkgd.shtml Severine, D. , & A ; Shahani, L. ( 2009 ) . An Introduction to the Human Development and Capability Approach: Freedom and Agency. Sterling, VA: Earthscan. TeachMDGs. ( 2010 ) . The Millennium Development Goals. Retrieved from hypertext transfer protocol: //teachmdgs.net/// United Nations. ( 2006 ) . The Millenium Development Goals Report: United Nations Development Program. Retrieved from www.undp.org/publications/MDGReport2006.pdf United Nations Millennium Development Goals. ( 2010 ) . Acme on the Millenium Development Goals. Retrieved from hypertext transfer protocol: //www.un.org/milleniumgoals/